"Ketoromide": Replacing the "ester" by "amide" bond to covert 1,2,3-triazolyl ester to amide (of Ketorolac)"Ketoromide" as "Food Additive" rather than Therapeutic! Let's get out from "Shackle" (="FDA" Clinical Trials)!

In the end of 2015, our team made 1,2,3-triazolyl ester of Ketorolac (15K), boosting the "cell-permeability" of Ketorolac, an old pain-killer, over 500 times! However, the ester bond of "15K" might be cleaved in our body. So we could replace this "ester" bond, simply by "amide" bond, which might be more resistant to so-called "metabolism" in our body. This "amide" product may be called "24K", or "Ketoromide", which sounds like a highly potent version of "Thalidomide". ha, ha.

Please don't worry about "teratogenesis"! This new product will not produce so-called "Thalidomide" babies/angels. Unlike Thalidomide, Ketorolac has never been "teratogenic"! Thalidomide is a PAK1-blocker, and its amino derivative called "Pomalidomide" (POM in short) is no longer "teratogenic", although it is still a PAK1-blocker. Thus, PAK1-blocking activity has nothing to do with the "teratogenesis". Actually "PAK1-deficient" mice are very healthy, but live 60% longer than the wild-type.

We might use "Ketoromide" as a "Food Additive" (for promoting the "longevity") rather than a "therapeutic" drug against special diseases such as cancers and AD, so that it can be marketed more quickly, avoiding a "time and money" consuming clinical trials (called "Shackle")!
This will be our "new" stragedy! Otherwise the time is running out. I am 80, and "little" time is left before I shall go to "another" world (soon or later). So "Ketoromide" will be my "gift" (or will) to this world...