Great News for "Cachexia": Vitamin K2 (Menaquinone 7) derived from "Natto" (Japanese Fermented Soybeans) is among the best Natural therapeutics for Cachexia!

“Cachexia” is a complex disease (basically an “acute” ageing process towards "death") often associated with pancreatic cancer that causes a loss of appetite, hairs, muscles, bones, and body fats etc. It is known to depend on two major pathogenic / ageing kinases, PAK1 and TOR. MK7 is known to block PAK1 as described previously. Recently a Chinese group found that MK7 blocks TOR as well, easing cachexia in mouse model (1):

REFERENCE:
1. Y Zhang, Y Wang, Z Ming et al (2025).
Vitamin K2 Alleviates Insulin Resistance Associated Skeletal Muscle Atrophy via the AKT/mTOR Signalling Pathway. J Cachexia Sarcopenia Muscle. 16(3): e13840.

Since MK7 is among the most potent natural elixirs that extend lifespan of C. elegans, it is most likely that MK7 could be a potent therapeutic for cachexia as well.
In a sense, "Osteoporosis" appears to be a part of "Cachexia", and combination of vitamin D3 and K2 (MK2) is well known to "synergistically" ease Osteoporosis. Thus, this (D3 and K2) combination will be the solution of Cachexia as well. indeed, D3 is known to block both PAK1 and TOR as MK2.