Conclusion: Ultimate Recipe for Longevity, by blocking both PAK1 and TOR at a delicate balance, not damaging "Immune" system, but abolishing "Cachexia" (premature ageing/death). "Fucoidan" from Brown Seaweeds could block Cachexia, by activating LKB1 that eventually blocks both PAK1 and TOR !

It has been known that blocking either PAK1 or TOR extends the lifespan of both C. elegans and mice. However, blocking TOR alone suppresses our "immune" system, while blocking PAK1 alone stimulates our "immune" system in Mammals.
It is also known that "Cachexia" (premature ageing/death) often caused by pancreatic cancers requires both PAK1 and TOR.
Thus, now the critical/techinal question has arisen, how can we block "Cachexia" without damaging our "Immune" system?
Very interestingly, PAK1 and TOR have an "opposite" effect on melanogenesis, as well as "Immune" system: PAK1 activates melanogenesis while TOR suppresses melanogenesis. . In other words PAK1-blockers (such as Propolis) suppress melanogenesis in cell (B16F10 melanoma) culture, while TOR blockers such as "Rapamycin" stimulate melanogenesis.
Thus, if you mix a PAK1-blocker and a TOR-blocker at a "proper" ratio, this mixture has no effect on melanogenesis in cell culture, and hopefully on our immune system as well.
Since the immune suppressive (side) effect of TOR blockers, so far they have been used only for "organ transplantation" in human.
Thus, if we can figure out the "proper" ratio of each PAK1-blocker and TOR-blocker, through melanogenesis assay, we would be able to use this combination for treatment of "Cachexia" and eventually "promoting our logevity".
https://pubmed.ncbi.nlm.nih.gov/37092555/
According to the above article (2023) by University of Texas in Dallas, loss of function mutation of LKB1 gene causes "Cachexia". Interestingly, LKB1 activates AMPK and eventually blocks TOR, as well as inactivating PAK1. Thus, LKB1 activators block both PAK1 and TOR, which are responsible for "Cachexia".
https://pubmed.ncbi.nlm.nih.gov/36276641/#&gid=article-figures&pid=figure-13-uid-12
A Chinese group recently developed/discovered a new LKB1 activator, "PA-S14" from a marine organism (for detail, see the above article in 2022).
https://pubmed.ncbi.nlm.nih.gov/39547407/
According to the above article in 2025 from a Chinese group, Fucoidan activates LKB1, thus blocking both PAK1 and TOR, indicating that this sulphated polysaccharide from brown sea weeds, could block "Cachexia".