PAK の下流、MEKを阻害すると、ショウジョウバエの寿命が２倍に延長！NF2 患者の寿命を２倍に延ばす可能性あり！

It is most likely that RAS-induced "premature" death requires RAF-MEK-ERK signalling pathway (just downstream of PAK1). According to 2015 article by a German team at Max-Planck Institute for Biol. of Ageing, Cologne, blocking RAS-ERK signalling by MEK inhibitor developed by GSK (Trametinib or Mekinist) extends the lifespan of Drosophila by 100%!
Trametinib, an FDA-approved drug (in 2014) for therapy of melanoma, is a highly specific inhibitor against MEK, preventing the activation of ERK by RAS (Yamaguchi et al., 2011) with IC50 around 10 micro M.
REF:
C Slack, N Alic, A Foley, et al (2015).
The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity.
Cell. 162(1):72-83.

多細胞生物（線虫、ショウジョウバエ、マウスなど）では、RAS-PI3K-PAK-RAF-MEK経路を遮断しても、寿命の延びは、せいぜい2倍だが、単細胞の“酵母”では、RASを遮断すると、寿命が６倍も伸びる！従って、往年の喜劇俳優（フランキー堺）なら、”私は、（貝ではなく）酵母になりたい“というかもしれない。